Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives.
Identifieur interne : 000079 ( Main/Exploration ); précédent : 000078; suivant : 000080Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives.
Auteurs : Lilya Kopertekh [Allemagne] ; Joachim Schiemann [Allemagne]Source :
- Current medicinal chemistry [ 1875-533X ] ; 2019.
Descripteurs français
- KwdFr :
- Agrobacterium tumefaciens (génétique), Anticorps monoclonaux (biosynthèse), Anticorps monoclonaux (usage thérapeutique), Ebolavirus (immunologie), Fièvre hémorragique à virus Ebola (thérapie), Génie génétique (MeSH), Humains (MeSH), Plantes (génétique), Planticorps (génétique), Planticorps (métabolisme), Planticorps (usage thérapeutique), Préparations pharmaceutiques (MeSH), Vecteurs génétiques (MeSH), Évolution moléculaire (MeSH).
- MESH :
- biosynthèse : Anticorps monoclonaux.
- génétique : Agrobacterium tumefaciens, Plantes, Planticorps.
- immunologie : Ebolavirus.
- métabolisme : Planticorps.
- thérapie : Fièvre hémorragique à virus Ebola.
- usage thérapeutique : Anticorps monoclonaux, Planticorps.
- Génie génétique, Humains, Préparations pharmaceutiques, Vecteurs génétiques, Évolution moléculaire.
English descriptors
- KwdEn :
- Agrobacterium tumefaciens (genetics), Antibodies, Monoclonal (biosynthesis), Antibodies, Monoclonal (therapeutic use), Ebolavirus (immunology), Evolution, Molecular (MeSH), Genetic Engineering (MeSH), Genetic Vectors (MeSH), Hemorrhagic Fever, Ebola (therapy), Humans (MeSH), Pharmaceutical Preparations (MeSH), Plantibodies (genetics), Plantibodies (metabolism), Plantibodies (therapeutic use), Plants (genetics).
- MESH :
- chemical , biosynthesis : Antibodies, Monoclonal.
- genetics : Agrobacterium tumefaciens, Plantibodies, Plants.
- immunology : Ebolavirus.
- chemical , metabolism : Plantibodies.
- chemical , therapeutic use : Antibodies, Monoclonal, Plantibodies.
- therapy : Hemorrhagic Fever, Ebola.
- Evolution, Molecular, Genetic Engineering, Genetic Vectors, Humans, Pharmaceutical Preparations.
Abstract
During the last two decades, the production of pharmaceutical proteins in plants evolved from proof of concept to established technology adopted by several biotechnological companies. This progress is particularly based on intensive research starting stable genetic transformation and moving to transient expression. Due to its advantages in yield and speed of protein production transient expression platforms became the leading plant-based manufacturing technology. Current transient expression methods rely on Agrobacteriummediated delivery of expression vectors into plant cells. In recent years, great advances have been made in the improvement of expression vectors, host cell engineering as well as in the development of commercial manufacturing processes. Several GMP-certified large-scale production facilities exist around the world to utilize agroinfiltration method. A number of pharmaceutical proteins produced by transient expression are currently in clinical development. The great potential of transient expression platform in respect to rapid response to emerging pandemics was demonstrated by the production of experimental ZMapp antibodies against Ebola virus as well as influenza vaccines. This review is focused on current design, status and future perspectives of plant transient expression system for the production of biopharmaceutical proteins.
DOI: 10.2174/0929867324666170718114724
PubMed: 28721831
Affiliations:
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(immunologie)</term><term>Fièvre hémorragique à virus Ebola (thérapie)</term><term>Génie génétique (MeSH)</term><term>Humains (MeSH)</term><term>Plantes (génétique)</term><term>Planticorps (génétique)</term><term>Planticorps (métabolisme)</term><term>Planticorps (usage thérapeutique)</term><term>Préparations pharmaceutiques (MeSH)</term><term>Vecteurs génétiques (MeSH)</term><term>Évolution moléculaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Agrobacterium tumefaciens</term><term>Plantibodies</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Agrobacterium tumefaciens</term><term>Plantes</term><term>Planticorps</term></keywords><keywords scheme="MESH" 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The great potential of transient expression platform in respect to rapid response to emerging pandemics was demonstrated by the production of experimental ZMapp antibodies against Ebola virus as well as influenza vaccines. 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This progress is particularly based on intensive research starting stable genetic transformation and moving to transient expression. Due to its advantages in yield and speed of protein production transient expression platforms became the leading plant-based manufacturing technology. Current transient expression methods rely on Agrobacteriummediated delivery of expression vectors into plant cells. In recent years, great advances have been made in the improvement of expression vectors, host cell engineering as well as in the development of commercial manufacturing processes. Several GMP-certified large-scale production facilities exist around the world to utilize agroinfiltration method. A number of pharmaceutical proteins produced by transient expression are currently in clinical development. The great potential of transient expression platform in respect to rapid response to emerging pandemics was demonstrated by the production of experimental ZMapp antibodies against Ebola virus as well as influenza vaccines. This review is focused on current design, status and future perspectives of plant transient expression system for the production of biopharmaceutical proteins.</AbstractText><CopyrightInformation>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kopertekh</LastName><ForeName>Lilya</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Federal Research Centre for Cultivated Plants, Institute for Biosafety in Plant Biotechnology, Erwin-Baur- Str. 27, D-06484, Quedlinburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schiemann</LastName><ForeName>Joachim</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Federal Research Centre for Cultivated Plants, Institute for Biosafety in Plant Biotechnology, Erwin-Baur- Str. 27, D-06484, Quedlinburg, 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